Daniel L Kaufman Selected Research

tramiprosate

1/2021	Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis.
1/2021	GABAA-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice.
10/2020	GABA administration prevents severe illness and death following coronavirus infection in mice.
10/2019	Homotaurine Treatment Enhances CD4+ and CD8+ Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice.
11/2018	Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis.

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Daniel L Kaufman Research Topics

Disease

16	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2023 - 03/2004
7	Autoimmune Diseases (Autoimmune Disease) 01/2023 - 12/2002
6	Rheumatoid Arthritis 01/2023 - 01/2011
5	COVID-19 01/2023 - 10/2020
5	Hyperglycemia 10/2019 - 07/2006
4	Inflammation (Inflammations) 01/2023 - 01/2011
4	Multiple Sclerosis 01/2023 - 11/2018
4	Infections 01/2022 - 10/2013
3	Pneumonia (Pneumonitis) 01/2022 - 10/2020
2	Type 2 Diabetes Mellitus (MODY) 01/2023 - 05/2011
2	Acute Lung Injury 01/2022 - 01/2021
2	Disease Progression 01/2021 - 10/2004
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2021 - 01/2011
2	Coronavirus Infections 01/2021 - 10/2020
2	Obesity 12/2019 - 01/2011
2	Parkinson Disease (Parkinson's Disease) 10/2013 - 01/2011
1	Neoplasms (Cancer) 01/2023
1	Sialadenitis 01/2022
1	Sjogren's Syndrome (Sjogren Syndrome) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Virus Diseases (Viral Diseases) 01/2021
1	Paralysis (Palsy) 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 11/2018
1	Gastroesophageal Reflux (GERD) 01/2017
1	Experimental Arthritis 09/2011
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2011
1	Glucose Intolerance 01/2011
1	Insulin Resistance 01/2011
1	Body Weight (Weight, Body) 01/2011
1	Liver Neoplasms (Liver Cancer) 08/2008
1	Carcinoma (Carcinomatosis) 08/2008

Drug/Important Bio-Agent (IBA)

14	gamma-Aminobutyric Acid (GABA)IBA 01/2023 - 10/2004
7	AntigensIBA 01/2022 - 08/2005
6	GABA Receptors (GABA Receptor)IBA 01/2023 - 01/2011
5	tramiprosateIBA 01/2021 - 11/2018
5	Glucose (Dextrose)FDA LinkGeneric 05/2011 - 03/2004
4	Aminobutyrates (Aminobutyric Acid)IBA 10/2019 - 01/2011
2	VaccinesIBA 01/2023 - 01/2011
2	AutoantigensIBA 12/2019 - 12/2002
2	ProinsulinIBA 09/2014 - 05/2011
2	BCG Vaccine FDA Link 10/2013 - 01/2011
2	Dopamine (Intropin)FDA LinkGeneric 10/2013 - 01/2011
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2013 - 01/2011
1	Antiviral Agents (Antivirals)IBA 01/2023
1	LigandsIBA 01/2023
1	EpitopesIBA 01/2022
1	ChemokinesIBA 01/2022
1	GABA Agonists (GABA Receptor Agonists)IBA 01/2022
1	preproinsulinIBA 01/2022
1	K-18 conjugate (K18)IBA 01/2022
1	CytokinesIBA 01/2022
1	Therapeutic UsesIBA 01/2021
1	Baclofen FDA LinkGeneric 01/2021
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2021
1	Amyloid (Amyloid Fibrils)IBA 11/2018
1	Amino Acids FDA Link 11/2018
1	lesogaberanIBA 01/2017
1	aluminum sulfate (alum)IBA 09/2014
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 10/2013
1	Streptozocin (Streptozotocin)FDA Link 05/2011
1	Thymidine KinaseIBA 05/2011
1	Ganciclovir (Cytovene)FDA LinkGeneric 05/2011
1	Proteins (Proteins, Gene)FDA Link 01/2011
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2011
1	Blood Glucose (Blood Sugar)IBA 01/2011
1	2,2'- azino- di- (3- ethylbenzothiazoline)- 6- sulfonic acid (ABTS)IBA 01/2011
1	1,2,5-oxadiazole 2-oxideIBA 08/2008
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2008
1	Oleanolic AcidIBA 08/2008
1	Superoxides (Superoxide)IBA 10/2004
1	N,N'- bis(salicylideneamino)ethane- manganese(II)IBA 10/2004
1	Free Radical ScavengersIBA 10/2004
1	Oxygen (Dioxygen)IBA 10/2004
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2004
1	Nitrogen OxidesIBA 10/2004
1	NitrogenIBA 10/2004
1	disalicylaldehyde ethylenediamine (salen)IBA 10/2004
1	ManganeseIBA 10/2004
1	Peroxynitrous Acid (Peroxynitrite)IBA 10/2004

Therapy/Procedure

8	Therapeutics 01/2023 - 03/2004
3	Immunotherapy 01/2022 - 02/2006
3	Islets of Langerhans Transplantation 12/2006 - 03/2004
1	Transplantation 01/2011